Topical finasteride has some similarities in efficacy to oral finasteride. Theoretically and according to some studies, it may have a relatively smaller impact on sexual function. However, it’s not accurate to say that their effects are exactly the same and that the topical form can completely avoid impacts on sexual function. Here is a detailed analysis:
In terms of Efficacy
Similarities
- Same principle of action: Both topical and oral finasteride work by inhibiting 5α – reductase, reducing the conversion of testosterone to dihydrotestosterone (DHT). This alleviates the adverse effects of DHT on tissues such as hair follicles and the prostate, providing a similar basis for treating androgenetic alopecia and benign prostatic hyperplasia.
- Some similar effects: When treating androgenetic alopecia, both topical and oral finasteride can, to a certain extent, promote hair growth, increase hair volume, and improve hair density and quality. In the treatment of benign prostatic hyperplasia, both can reduce the volume of the prostate, thereby relieving some symptoms such as difficulty in urination.
Differences
- Absorption and scope of action: Oral finasteride is absorbed through the gastrointestinal tract and enters the bloodstream, enabling it to act systemically and more comprehensively reduce the level of DHT in the body. Topical finasteride is mainly absorbed through skin penetration. The amount of absorption is relatively small, and it mainly acts locally, with a relatively weaker inhibitory effect on systemic DHT.
- Speed of efficacy manifestation: Generally, when treating hair loss and benign prostatic hyperplasia, oral finasteride can show relatively obvious effects within 3 – 6 months. Due to its absorption and action characteristics, topical finasteride may require more than 6 months to show obvious effects, and its efficacy is lower than that of the oral form, but it may cause less harm to the body.
In terms of the Impact on Sexual Function
Oral finasteride: Clinical studies indicate that oral finasteride may have a certain impact on sexual function, with an incidence rate of approximately 1.8% – 4.8%. Common side effects include decreased libido, erectile dysfunction, and ejaculation abnormalities. This is because the drug affects the metabolism and level of androgens in the body through the bloodstream, potentially interfering with the normal function of the reproductive system.
Topical finasteride
- Theoretical advantages: Topical finasteride acts directly on the local area, with a relatively small amount of the drug entering the bloodstream, thus having a relatively minor impact on the systemic androgen level. Therefore, theoretically, its impact on sexual function may be less than that of oral finasteride.
- Actual situation: Currently, research data on the impact of topical finasteride on sexual function are relatively limited. Some studies show that the incidence of sexual dysfunction it causes is relatively low, but some users have reported mild sexual function problems similar to those of the oral preparation, such as a slight decrease in libido. This may be related to factors such as individual differences in skin absorption, and not all users can completely avoid impacts on sexual function.
Topical finasteride has its own characteristics in terms of efficacy and impact on sexual function compared to oral finasteride. It’s not definite that their effects are similar and that the topical form will necessarily reduce the impact on sexual function. When choosing a treatment method, factors such as the patient’s specific condition, expected efficacy, and tolerance to side effects need to be comprehensively considered, and a decision should be made under the guidance of a doctor.